Novel pyridine-1,3,4-oxadiazole linked 1,2,3-triazole hybrids: synthesis, molecular docking, ADME, DFT study and anti-tumor potential

Novel pyridine-1,3,4-oxadiazole linked 1,2,3-triazole hybrids: synthesis, molecular docking, ADME, DFT study and anti-tumor potential

Ten novel pyridine-1,3,4-oxadiazole-linked 1,2,3-triazole hybrids (1a-j) were synthesized via a five-step strategy incorporating diverse aromatic substituents with electron-donating and withdrawing groups. Their biological evaluation using the Allium cepa model revealed notable anti-mitotic activity...

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Bibliographic Details
Main Authors: Aezaz Mathakiya, Bonny Patel, Keval Raval, Jignesh H. Kamdar, Smriti Sharma, Jayesh Dhalani
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Results in Chemistry
Subjects:
ADME
Anti-cancer
Pyridine
1,2,3-Triazole
1,3,4-Oxadiazole
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625005041
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