Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection.

Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection.

NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. We have previously demonstrated that they upregulate the death ligand TRAIL in patients with chronic hepatitis B virus infection (CHB), allowing them to kill hepatocytes bearing TRAIL receptors. In this stud...

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Bibliographic Details
Main Authors: Dimitra Peppa, Lorenzo Micco, Alia Javaid, Patrick T F Kennedy, Anna Schurich, Claire Dunn, Celeste Pallant, Gidon Ellis, Pooja Khanna, Geoffrey Dusheiko, Richard J Gilson, Mala K Maini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001227&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001227&type=printable

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