Agmatine Mitigates Diabetes-Related Memory Loss in Female Mice by Targeting I<sub>2</sub>/I<sub>3</sub> Imidazoline Receptors and Enhancing Brain Antioxidant Defenses

Agmatine Mitigates Diabetes-Related Memory Loss in Female Mice by Targeting I<sub>2</sub>/I<sub>3</sub> Imidazoline Receptors and Enhancing Brain Antioxidant Defenses

Cognitive decline is a common complication of diabetes mellitus, driven in part by oxidative stress and impaired glucose–insulin homeostasis. This study examined the neuroprotective effects of agmatine (200 mg/kg intraperitoneally) in female BALB/c diabetic mice. Several receptor pathways were exami...

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Bibliographic Details
Main Authors: Luis E. Cobos-Puc, Hilda Aguayo-Morales
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antioxidants
Subjects:
agmatine
diabetes
female mice
memory
imidazoline receptor
antioxidants
Online Access:https://www.mdpi.com/2076-3921/14/7/837
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