TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis

TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis

Abstract The TGFβ signaling pathway is known for its pleiotropic functions in a plethora of biological processes. In melanoma, TGFβ signaling promotes invasiveness and metastasis formation. However, its involvement in the response to therapy is controversial. While several studies have linked TGFβ s...

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Main Authors: Benjamin Loos, Adrian Salas-Bastos, Anna Nordin, Julien Debbache, Salome Stierli, Phil F. Cheng, Stefanie Rufli, Conrad Wyss, Mitchell P. Levesque, Reinhard Dummer, Wendy Wei-Lynn Wong, Steve Pascolo, Claudio Cantù, Lukas Sommer
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07305-1
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https://doi.org/10.1038/s41419-024-07305-1

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