In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.

In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.

The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic cell development and induction of several inflammatory mediators. Here, we generated C/EBPβ and C/EBPε double-knockout (bbee) mice and compared their phenotypes to those of single deficient (bbEE and BBe...

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Main Authors: Tadayuki Akagi, Nils H Thoennissen, Ann George, Gay Crooks, Jee Hoon Song, Ryoko Okamoto, Daniel Nowak, Adrian F Gombart, H Phillip Koeffler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015419&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015419&type=printable

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