Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism

Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism

Abstract Tetrandrine (Tet) is a potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent. Using a clickable photoaffinity probe, we identify lysosomal integral membrane protein-2 (L...

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Main Authors: Wing-Cheung Chan, Qian Zhao, Koon Ho Wong, Hok-Him Tang, Daniel Kam-Wah Mok, Lakhansing Pardeshi, Ye Chun Ruan, Yang Yang, Chi-Ming Wong, Clarence T. T. Wong, Yong-Juan Zhao, Ka Ying Chan, Zengsheng Yin, Howard Ho-Wai Leung, Xiyang Ma, Mary P. Chau, Franco King-Chi Leung, Ying-Ying Lui, Shannon Wing-Ngor Au, Kailei Sun, Chin Yu Mok, Fang Wang, Cong Ma, Yu-Hin Ho, Xiang-Yang Ye, Man Lung Yeung, Yajing Zhang, Yan Xiang Zhao, Jiang Liu, Ka-Hing Wong, Larry M. C. Chow, Xiang David Li, Gary M. Tse, Man-Kin Wong, Xiao Shen, Pauline Chiu, Ben C. B. Ko
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61565-9
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https://doi.org/10.1038/s41467-025-61565-9

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