LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria

LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria

Antibodies (Abs) targeting the P3 sequence (Gly1127-Cys1140) of LDL receptor-related protein 1 (anti-P3 Abs) inhibit the interaction between ApoB100 in cholesteryl ester (CE)-enriched lipoproteins and the CR9 domain in LDL receptor-related protein 1, preventing intracellular CE accumulation induced...

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Bibliographic Details
Main Authors: A. Benitez-Amaro, E. Garcia, M.T. LaChica Lhoëst, A. Polishchuk, I. Zegri-Reiriz, D. Vilades, J.M. Guerra, L. Fernández-del-Rio, S. Mirabet, V. Samouillan, O. Shirihai, M. Liesa, C. Enrich, V. Llorente-Cortés
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Lipid Research
Subjects:
cholesteryl esters
heart
lipid droplets
LRP1
mitochondria
respirometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525000434
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