The short cytoplasmic region of phage T4 holin is essential for the transition from impermeable membrane protein complexes to permeable pores

Virulent as well as temperate phages usually require lysis of bacteria to release their progeny into the surrounding. Double-stranded DNA phages achieve lysis by phage-encoded endolysins that degrade the bacterial cell wall. Endolysins cross the cytoplasmic membrane by the aid of phage-encoded hole-...

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Bibliographic Details
Main Authors: Jan Michel Frederik Schwarzkopf, Ruth Paola Viveros, Ali Nazmi Burdur, Denise Mehner-Breitfeld, Natalia Tschowri, Thomas Brüser
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1579756/full
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