Mucosal vaccination with recombinant Lactobacillus casei-displayed CTA1-conjugated consensus matrix protein-2 (sM2) induces broad protection against divergent influenza subtypes in BALB/c mice.

Mucosal vaccination with recombinant Lactobacillus casei-displayed CTA1-conjugated consensus matrix protein-2 (sM2) induces broad protection against divergent influenza subtypes in BALB/c mice.

To develop a safe and effective mucosal vaccine against pathogenic influenza viruses, we constructed recombinant Lactobacillus casei strains that express conserved matrix protein 2 with (pgsA-CTA1-sM2/L. casei) or without (pgsA-sM2/L. casei) cholera toxin subunit A1 (CTA1) on the surface. The surfac...

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Main Authors: Mohammed Y E Chowdhury, Rui Li, Jae-Hoon Kim, Min-Eun Park, Tae-Hwan Kim, Prabuddha Pathinayake, Prasanna Weeratunga, Man Ki Song, Hwa-Young Son, Seung-Pyo Hong, Moon-Hee Sung, Jong-Soo Lee, Chul-Joong Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094051&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0094051&type=printable

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