GABAergic Influences on Medulloblastoma

GABAergic Influences on Medulloblastoma

Medulloblastoma (MB) is the most common malignant brain tumor in children and typically arises in the cerebellum, likely due to disruptions in neuronal precursor development. The primary inhibitory neurotransmitter in the central nervous system (CNS), γ-aminobutyric acid (GABA), exerts its effects t...

Full description

Saved in:

Bibliographic Details
Main Authors:	Viviane Aline Buffon, Jurandir M. Ribas Filho, Osvaldo Malafaia, Isadora D. Tassinari, Rafael Roesler, Gustavo R. Isolan
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Brain Sciences
Subjects:	γ-aminobutyric acid GABA<sub>A</sub> receptor <i>GABRA5</i> GABA<sub>A</sub> α5 subunit medulloblastoma pediatric brain cancer
Online Access:	https://www.mdpi.com/2076-3425/15/7/746
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Characterization of the Glutamate Decarboxylase (GAD) Gene and Functional Analysis of <i>DlGAD3</i> in the Accumulation of γ-Aminobutyric Acid in Longan (<i>Dimocarpus longan</i> Lour.) Pulp
by: Weilin Wei, et al.
Published: (2025-06-01)

Parenteral Nanoemulsion for Optimized Delivery of GL-II-73 to the Brain—Comparative In Vitro Blood–Brain Barrier and In Vivo Neuropharmacokinetic Evaluation
by: Kristina Jezdić, et al.
Published: (2025-03-01)

Role of 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> Receptors in Memory Regulation and the Importance of Their Coexpression: A Systematic Review
by: Alfredo Briones-Aranda, et al.
Published: (2025-05-01)

Synthesis and In Silico Evaluation of GABA, Pregabalin and Baclofen <i>N</i>-Heterocyclic Analogues as GABA<sub>B</sub> Receptor Agonists
by: Zuleyma Martínez-Campos, et al.
Published: (2025-03-01)

Unveiling microbial dynamics in terasi spontaneous fermentation: Insights into glutamate and GABA production
by: Gemilang Lara Utama, et al.
Published: (2025-01-01)

Dual Bioconversion Strategy: Synergistic Germination and <i>Lactobacillus</i> Fermentation Engineering for a γ-Aminobutyric Acid-Enriched Beverage from Brown Rice
by: Di Yuan, et al.
Published: (2025-08-01)

Gamma-Aminobutyric Acid: A Novel Biomolecule to Improve Plant Resistance and Fruit Quality
by: Jingrong Wang, et al.
Published: (2025-07-01)

Chloroplast Control Mechanisms by Molecular Electronic Device
by: Yuri Shapovalov, et al.
Published: (2024-04-01)

Effects of Ge-Doping on Thermoelectric Performance of Polycrystalline Cubic Sn<sub>0.5</sub>Ag<sub>0.25</sub>Bi<sub>0.25</sub>Se<sub>0.50</sub>Te<sub>0.50</sub>
by: Haoyu Zhao, et al.
Published: (2025-07-01)

Vanadium-Based MXenes: Types, Synthesis, and Recent Advances in Supercapacitor Applications
by: Zhiwei Gao, et al.
Published: (2025-07-01)

Сomplex doping niobium oxide with ionic conductivity.
by: V. V. Konovalova, et al.
Published: (2009-08-01)

Effects of Cu Substituting Mo in Sr<sub>2</sub>Fe<sub>1.5</sub>Mo<sub>0.5</sub>O<sub>6−δ</sub> Symmetrical Electrodes for CO<sub>2</sub> Electrolysis in Solid Oxide Electrolysis Cells
by: Wanting Tan, et al.
Published: (2025-04-01)

Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling
by: Jing Dong, et al.
Published: (2025-06-01)

Theoretical Insights into the Chemical Bonding, Electronic Structure, and Spectroscopic Properties of the Lanarkite Pb<sub>2</sub>SO<sub>5</sub> Structure
by: Guilherme S. L. Fabris, et al.
Published: (2025-06-01)

THE SYNTHESIS AND STUDY OF THE LUMINESCENCE PROPERTIES OF SOLID SOLUTIONS (Y<sub>1-X-Y-Z</sub>YB<sub>X</sub>ER<sub>Y</sub>HO<sub>Z</sub>)<sub>3</sub>AL<sub>5</sub>O<sub>12</sub> WITH LASER EXCITATION
by: Egor I. Pozdnyakov
Published: (2022-05-01)

An Investigation of WO<sub>3</sub>/V<sub>2</sub>O<sub>5</sub>/TiO<sub>2</sub> Catalysts: Effects of WO<sub>3</sub> on Morphology, Thermal Stability, and Activity for the Catalytic Oxidation of Dimethyl Sulfide
by: Gaytri Sharma, et al.
Published: (2025-06-01)

Effect on the Electrochemical Properties of PEO Films Produced on Commercially Pure Titanium Using Multicomponent Oxide Coatings
by: Lauri Ruberti, et al.
Published: (2025-06-01)

Comparative Analysis of Air Pollution in Beijing and Seoul: Long-Term Trends and Seasonal Variations
by: Hana Na, et al.
Published: (2025-06-01)

Electrostatic Self-Assembly of Heterostructured In<sub>2</sub>O<sub>3</sub>/Ti<sub>3</sub>C<sub>2</sub>T<i><sub>x</sub></i> Nanocomposite for High-Selectivity NO<sub>2</sub> Gas Sensing at Room Temperature
by: Yongjing Guo, et al.
Published: (2025-07-01)

Mg<sup>2+</sup> and Cr<sup>3+</sup> Co-Doped LiNi<sub>0.5</sub>Mn<sub>1.5</sub>O<sub>4</sub> Derived from Ni/Mn Bimetal Oxide as High-Performance Cathode for Lithium-Ion Batteries
by: Dehua Ma, et al.
Published: (2025-03-01)

Effects of [Zn<sub>0.5</sub>Si<sub>0.5</sub>]<sup>3+</sup> Substitution on Microwave Dielectric Properties of ZnAl<sub>2-<i>x</i></sub>(Zn<sub>0.5</sub>Si<sub>0.5</sub>)<i><sub>x</sub></i>O<sub>4</sub> Ceramics
by: Xuekai Lan, et al.
Published: (2025-07-01)

Rapid Genotyping of <i>FecB</i> Mutation in Sheep Using CRISPR-Cas12a Integrated with DNA Nanotree Biosensing Platform
by: Dongxia Pan, et al.
Published: (2025-02-01)

Exploring the Tribological Potential of Y<sub>2</sub>BaCuO<sub>5</sub> Precursor Powders as a Novel Lubricant Additive
by: Shuo Cheng, et al.
Published: (2025-07-01)

Defect-Induced Modulation of Electronic and Optical Properties in Monolayer CsPb<sub>2</sub>Br<sub>5</sub>: Implications for Fiber-Optic Sensing Applications
by: Meiqi An, et al.
Published: (2025-06-01)

Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder
by: N. A. Sukhorukova, et al.
Published: (2022-07-01)

SYNTHESIS AND STUDY OF THE INFRARED LUMINESCENCE OF SOLID SOLUTIONS (Y<sub>1-x</sub>Yb<sub>0,1</sub>Tm<sub>x</sub>)<sub>3</sub>Al<sub>5</sub>O<sub>12</sub> WITH LASER EXCITATION
by: Evgeny Igorevich Pozdnyakov
Published: (2022-05-01)

SPECTRUM OF RAMAN SCATTERING HETEROSTRUCTURES A<sub>3</sub>B<sub>5</sub>/Si (100) OBTAINED BY PULSED LASER DEPOSITION
by: Oleg Devitsky, et al.
Published: (2022-05-01)

Hot Corrosion Behavior of (Gd<sub>0.9</sub>Sc<sub>0.1</sub>)<sub>2</sub>Zr<sub>2</sub>O<sub>7</sub>/YSZ Thermal Barrier Coatings Exposed to V<sub>2</sub>O<sub>5</sub> + Na<sub>2</sub>SO<sub>4</sub> Molten Salt
by: GUO Lei, XIN Hui
Published: (2021-02-01)

Harnessing BiOI/V<sub>2</sub>O<sub>5</sub> Nanocomposites: Advanced Bifunctional Catalysts for Visible-Light Driven Environmental Remediation and Antibacterial Activity
by: Anil Pandey, et al.
Published: (2025-06-01)

Anodic Composite Nanostructure: Formation, Morphology, Optical and Photoluminescent Properties
by: A. V. Hoha, et al.
Published: (2022-08-01)

Polycyclic Aromatic Hydrocarbons in Atmospheric PM<sub>2.5</sub> and PM<sub>10</sub> of Riyadh City, Saudi Arabia: Levels, Temporal Variation, and Health Impacts
by: Hattan A. Alharbi, et al.
Published: (2025-05-01)

Microstructure and Electrochemical Properties of Pure and Vanadium-Doped Li<sub>4</sub>Ti<sub>5</sub>O<sub>12</sub> Nanoflakes for High Performance Supercapacitors
by: Mudda Deepak, et al.
Published: (2025-07-01)

Efficacy of Ventilation Air Purifiers in Improving Classroom Air Quality: A Case Study in South Korea
by: Jae Jung Lee, et al.
Published: (2025-04-01)

Exothermic and Slag Formation Behavior of Aluminothermic Reduction of Mo and V Oxides
by: Xiaoshu Wang, et al.
Published: (2025-06-01)

Neurofibromatosis: analysis of clinical cases and new diagnostic criteria
by: E. S. Makashova, et al.
Published: (2022-02-01)

Structural Analysis of Erbium-Doped Silica-Based Glass-Ceramics Using Anomalous and Small-Angle X-Ray Scattering
by: Helena Cristina Vasconcelos, et al.
Published: (2025-02-01)

Total Flavones of <i>Rhododendron</i> Protect Against Ischemic Cerebral Injury by Regulating the Phosphorylation of the RhoA-ROCK<sub>2</sub> Pathway via Endothelial-Derived H<sub>2</sub>S
by: Xiaoqing Sun, et al.
Published: (2025-07-01)

Growth and Characterization of Ga<sub>2</sub>O<sub>3</sub> for Power Nanodevices Using Metal Nanoparticle Catalysts
by: Badriyah Alhalaili, et al.
Published: (2025-07-01)

Modeling and Control of Tugboat-Assisted Operation for Marine Vessels
by: Jung-Suk Park, et al.
Published: (2025-04-01)

Gas and Steam Permeation Properties of Cation-Exchanged ZSM-5 Membrane
by: Yuichiro Hirota, et al.
Published: (2025-03-01)