Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency

Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency

Neutrophilic inflammation and a high level of free α-defensins are main features of chronic airway inflammation in alpha-1 antitrypsin-deficient (AATD) individuals. Despite the antimicrobial activities of α-defensins by direct bacterial killing and by modulation of immune responses, AATD individuals...

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Bibliographic Details
Main Authors: Jungnam Lee, Naweed Mohammad, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
alpha defensins
alpha 1 antitrypsin (AAT)
AAT deficiency (AATD)
neutrophils
macrophages
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1543729/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1543729/full

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