Safety profile of self-amplifying mRNA SARS-CoV-2 vaccine ARCT-154 in adults: a pooled phase 1/2/3 randomized clinical study

Safety profile of self-amplifying mRNA SARS-CoV-2 vaccine ARCT-154 in adults: a pooled phase 1/2/3 randomized clinical study

Background Public health concerns due to ongoing emergence of SARS-CoV-2 variants necessitates further development of improved COVID-19 vaccines. One major innovation are self-amplifying mRNA vaccines, such as ARCT-154 (Arcturus Therapeutics, Inc.), which induces superior immunogenicity compared wit...

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Main Authors: Nhan Thi Ho, Igor Smolenov, Ly Thi Le Tran, Van Thu Nguyen, Van Thanh Ta, Thuong Vu Nguyen, Hung Ngoc Pham, Anh Thi Van Pham, Quang Chan Luong, Men Van Chu, Mai Thi Ngoc Dang, Toan Trong Nguyen, Vy Thi Tuong Le, Quang Vinh Trinh, Thang Van Nguyen, Anh Ngoc Nguyen, Ha Thai Pham, Giang Duc Dao, Carmen Baccarini, Ekpeno Nnah, Alia Hawkes, Suezanne Parker, Carole Verhoeven, Judd L Walson, Xuan-Hung Nguyen
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Expert Review of Vaccines
Subjects:
COVID-19 vaccine
reactogenicity
safety
SARS-COV-2
Self-amplifying mRNA
Online Access:https://www.tandfonline.com/doi/10.1080/14760584.2025.2487542
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https://www.tandfonline.com/doi/10.1080/14760584.2025.2487542

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