Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes

Ubiquitin‐specific protease 25 improves myocardial ischemia–reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes

Abstract Background Myocardial ischemia/reperfusion injury (MI/RI) restricts the effect of myocardial reperfusion therapy and lacks effective prevention and treatment methods. Deubiquitinating enzymes (DUBs), especially members of the ubiquitin‐specific protease (USP) family of DUBs, are key protein...

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Bibliographic Details
Main Authors: Bozhi Ye, Diyun Xu, Lingfeng Zhong, Yi Wang, Wei Wang, Haowen Xu, Xue Han, Julian Min, Gaojun Wu, Wenhai Huang, Guang Liang
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Subjects:
cardiomyocyte
myocardial ischemia–reperfusion injury
NLRP3
pyroptosis
ubiquitin‐specific protease 25
Online Access:https://doi.org/10.1002/ctm2.70243
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https://doi.org/10.1002/ctm2.70243

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