Comparison of biodegradable and metal occluders in patients with PFO and migraine: study design and rationale of BioMetal Trial

Comparison of biodegradable and metal occluders in patients with PFO and migraine: study design and rationale of BioMetal Trial

Abstract Background The association between migraine and patent foramen ovale (PFO) has led to investigations into percutaneous PFO closure as a potential therapeutic avenue. While existing trials with metal occluders have shown promise in reducing migraine burden, concerns over long-term complicati...

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Bibliographic Details
Main Authors: Ziping Li, Jie Dong, Jing Dong, Yiming Yan, Manchen Gao, Fang Fang, Fengwen Zhang, Wenbin Ouyang, Shouzheng Wang, Chuangshi Wang, Xiangbin Pan, BioMetal investigators
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Trials
Subjects:
Migraine
Patent foramen ovale
Randomized controlled trial
Biodegradable occluder
Metal occluder
Online Access:https://doi.org/10.1186/s13063-025-09011-5
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https://doi.org/10.1186/s13063-025-09011-5

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