Novel derivative of nicotinic acid ameliorates doxorubicin-induced cardiac injury via regulation of redox homeostasis

Novel derivative of nicotinic acid ameliorates doxorubicin-induced cardiac injury via regulation of redox homeostasis

Introduction: Doxorubicin (DOX) is an anthracycline antibiotic with considerable significance in clinics as an anticancer agent, which is limited by its cardiotoxicity, though. A large number of possible therapeutic strategies for reducing cardiotoxicity with doxorubicin have been studied. However,...

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Main Authors: Yana V. Loboda, Mikhail V. Korokin, Alexey V. Kuznetsov, Tatiana N. Malorodova, Anton P. Danilenko, Anna A. Peresypkina, Oleg S. Gudyrev, Ol’ga A. Kop’eva, Tatyana G. Pokrovskaya, Liliya V. Korokina, Valeriya N. Khruslova, Valeriya A. Nazarenko, Tatyana V. Avtina, Alexey V. Deikin, Aleksandr A. Dolzhikov, Tatiana V. Puzanova, Lyudmila M. Danilenko
Format: Article
Language:English
Published: Belgorod National Research University 2024-09-01
Series:Research Results in Pharmacology
Subjects:
potassium 5-hydroxynicotinate
doxorubicin
coefficient stттi
oxidative stress
wistar rats
Online Access:https://rrpharmacology.ru/index.php/journal/article/view/514
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