Increased [<sup>18</sup>F]DPA-714 Uptake in the Skeletal Muscle of SOD1<sup>G93A</sup> Mice: A New Potential of Translocator Protein 18 kDa Imaging in Amyotrophic Lateral Sclerosis

Increased [<sup>18</sup>F]DPA-714 Uptake in the Skeletal Muscle of SOD1<sup>G93A</sup> Mice: A New Potential of Translocator Protein 18 kDa Imaging in Amyotrophic Lateral Sclerosis

Purpose: The skeletal muscle has been proposed to contribute to the progressive loss of motor neurons typical of amyotrophic lateral sclerosis (ALS). However, this mechanism has not yet been clarified due to the lack of suitable imaging tools. Here, we aimed to verify whether PET imaging of the tran...

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Main Authors: Cecilia Marini, Mattia Riondato, Edoardo Dighero, Alessia Democrito, Serena Losacco, Laura Emionite, Lucilla Nobbio, Irene Di Patrizi, Mattia Camera, Chiara Ghersi, Maddalena Ghelardoni, Francesco Lanfranchi, Francesca Vitale, Sonia Carta, Sabrina Chiesa, Carola Torazza, Marco Milanese, Matteo Bauckneht, Mehrnaz Hamedani, Federico Zaottini, Angelo Schenone, Carlo Martinoli, Federica Grillo, Gianmario Sambuceti
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
[<sup>18</sup>F]DPA-714
TSPO
PET
ALS
skeletal muscle
brain
Online Access:https://www.mdpi.com/2218-273X/15/6/799
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