Physiologically Based Pharmacokinetic Simulation of Tofacitinib in Humans Using Extrapolation from Single-Species Renal Failure Model

Physiologically Based Pharmacokinetic Simulation of Tofacitinib in Humans Using Extrapolation from Single-Species Renal Failure Model

<b>Background/Objectives:</b> Tofacitinib is a Janus kinase 1 and 3 inhibitor that was developed to treat rheumatoid arthritis. Accordingly, this study aimed to predict plasma tofacitinib concentrations and pharmacokinetic parameters in patients with renal failure through physiologically...

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Bibliographic Details
Main Authors: Sung Hun Bae, So Yeon Park, Hyeon Gyeom Choi, So Hee Kim
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceutics
Subjects:
tofacitinib
single-species extrapolation
renal failure
PBPK simulation
Online Access:https://www.mdpi.com/1999-4923/17/7/914
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