Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis

Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis

IntroductionThis study investigates the therapeutic potential of blocking key CD4+ Th1 effector cytokines, TNF-α and IFN-γ, in experimental anti-myeloperoxidase (MPO) glomerulonephritis (GN). The immunopathogenesis of MPO autoimmunity is biphasic, with an initial transient Th17 dominance followed by...

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Bibliographic Details
Main Authors:	Kei Nagai, Daniel Koo Yuk Cheong, Anne Cao Le, Diana Shu Yee Tan, Joshua Daniel Ooi, Poh-Yi Gan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Immunology
Subjects:	autoimmune disease ANCA-associated vasculitis glomerulonephritis antigen specific T cells anti-cytokine biologics
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589130/full
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