Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis

Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis

IntroductionThis study investigates the therapeutic potential of blocking key CD4+ Th1 effector cytokines, TNF-α and IFN-γ, in experimental anti-myeloperoxidase (MPO) glomerulonephritis (GN). The immunopathogenesis of MPO autoimmunity is biphasic, with an initial transient Th17 dominance followed by...

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Main Authors: Kei Nagai, Daniel Koo Yuk Cheong, Anne Cao Le, Diana Shu Yee Tan, Joshua Daniel Ooi, Poh-Yi Gan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
autoimmune disease
ANCA-associated vasculitis
glomerulonephritis
antigen specific
T cells
anti-cytokine biologics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589130/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589130/full

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