Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches

Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches

Abstract Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia. The study aimed to develop and optimize the transdermal matrix patch of clozapine. A 3-level, 3-factor Central Composite Design was applied to examine and validate the impact of various...

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Main Authors: Abdul Qadir, Syed Umer Jan, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Fatima Ramzan Ali, Fahad Siddiqui, Abdul Jabbar Magsi, Ghulam Mustafa, Muhammad Talha Saleem, Shafi Mohammad, Mohammad Younis, Muhammad Arsalan
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Central composite design
PBPK
Transdermal drug delivery
Permeation enhancers, in silico
In vitro
In vivo
Online Access:https://doi.org/10.1038/s41598-024-81918-6
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https://doi.org/10.1038/s41598-024-81918-6

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