Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH

Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH

Abstract Wall teichoic acid (WTA) is a polyol phosphate polymer that covalently decorates peptidoglycan of gram-positive bacteria, including Staphylococcus aureus. Central to WTA biosynthesis is flipping of lipid-linked precursors across the cell membrane by TarGH, a type V ABC transporter. Here, we...

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Bibliographic Details
Main Authors: Franco K. K. Li, Shaun C. Peters, Liam J. Worrall, Tianjun Sun, Jinhong Hu, Marija Vuckovic, Maya Farha, Armando Palacios, Nathanael A. Caveney, Eric D. Brown, Natalie C. J. Strynadka
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58202-w
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https://doi.org/10.1038/s41467-025-58202-w

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