The a subunit isoforms of V-ATPase are involved in glucose-dependent trafficking of insulin granules

The a subunit isoforms of V-ATPase are involved in glucose-dependent trafficking of insulin granules

Abstract In pancreatic β cells, insulin granules move toward the plasma membrane to secrete insulin upon glucose stimulation, but the amount of secreted insulin is only a small portion of the total, and many granules do not release insulin. Here, using MIN6 cells derived from mouse pancreatic β cell...

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Main Authors: Mizuki Sekiya, Mayumi Nakanishi-Matsui, Naomi Matsumoto, Iwao Takahashi, Tomohito Hanasaka, Eri Ishiyama-Matsuura, Makoto Araki, Tomohiko Wakayama, Koji Nata
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
V-ATPase
a subunit isoforms
Insulin secretion
Membrane trafficking
Rab27A
Online Access:https://doi.org/10.1038/s41598-025-02997-7
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https://doi.org/10.1038/s41598-025-02997-7

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