Two‐period linear mixed effects models to analyze clinical trials with run‐in data when the primary outcome is continuous: Applications to Alzheimer's disease
Abstract Introduction Study outcomes can be measured repeatedly based on the clinical trial protocol before randomization during what is known as the “run‐in” period. However, it has not been established how best to incorporate run‐in data into the primary analysis of the trial. Methods We proposed...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.trci.2019.07.007 |
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