Emerging biophysical origins and pathogenic implications of amyloid oligomers

Abstract The amyloid hypothesis has been a leading narrative concerning the pathophysiological foundation of Alzheimer’s and Parkinson’s disease. At the two ends of the hypothesis lie the functional protein monomers and the pathology-defining amyloid fibrils, while the early stages of protein aggreg...

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Bibliographic Details
Main Authors: Huayuan Tang, Nicholas Andrikopoulos, Yuhuan Li, Stone Ke, Yunxiang Sun, Feng Ding, Pu Chun Ke
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58335-y
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