Study on the CHJ01 antitumor activity and mechanism via targeting sphingosine kinase 1 in A549 cells

The SphK1 inhibitor development is of great importance for the treatment of non-small cell lung cancer (NSCLC). In this study, CHJ01 which has been previously shown anti-tumor effects was introduced to investigate the detailed antitumor mechanism both in vitro and in vivo. CHJ01 inhibited the A549 ​...

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Bibliographic Details
Main Authors: Caiyu Liu, Shengmei Gao, Bo Liu, Feipeng Zhang, Yanling Mu, Fuwen Wang, Yan Li
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Pharmaceutical Science Advances
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Online Access:http://www.sciencedirect.com/science/article/pii/S2773216925000157
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