Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma cell proliferation and modified the sensitivi...

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Main Authors: Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.
Format: Article
Language:English
Published: Sciendo 2024-01-01
Series:Endocrine Regulations
Subjects:
ern1 knockdown
glucose deprivation
glutamine deprivation
psat1
psph
atf4
gene expression
u87mg glioblastoma cells
Online Access:https://doi.org/10.2478/enr-2024-0010
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https://doi.org/10.2478/enr-2024-0010

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