Activated GDF11/8 subforms predict cardiovascular events and mortality in humans

Activated GDF11/8 subforms predict cardiovascular events and mortality in humans

Abstract Circulating Growth Differentiation Factors 11 and 8 (GDF11/8) exist in both latent and active forms, and it is unclear if specific forms can predict disease outcomes. Our data suggest that a dual-specific aptamer selectively binds GDF11/8 after prodomain activation. In 11,609 patients at ri...

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Main Authors: Ryan G. Walker, Tomohiro Kato, Laura Ben Driss, Stephen A. Williams, Michael A. Hinterberg, Nebojsa Janjic, Amy D. Gelinas, Meredith A. Carpenter, Chandramohan Kattamuri, Joan E. Walter, Christian Mueller, Kourtney R. Mendello, Justis V. Gordon, Keenan A. Walker, Josef Coresh, Shalender Bhasin, Lee L. Rubin, Amy J. Wagers, Thomas B. Thompson, Peter Ganz, Richard T. Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61815-w
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https://doi.org/10.1038/s41467-025-61815-w

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