Anticipating Leucovorin Rescue Therapy in Patients with Osteosarcoma through Methotrexate Population Pharmacokinetic Model

Anticipating Leucovorin Rescue Therapy in Patients with Osteosarcoma through Methotrexate Population Pharmacokinetic Model

Methotrexate (MTX), which presents high inter-individual variability, is part of the Brazilian Osteosarcoma Treatment Group (BOTG) protocol. This work aimed to develop a MTX population pharmacokinetic model (POPPK) for Brazilian children with osteosarcoma (OS) following the BOTG protocol to guide re...

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Main Authors: Laura Ben Olivo, Pricilla de Oliveira Henz, Sophia Wermann, Bruna Bernar Dias, Gabriel Osorio Porto, Amanda Valle Pinhatti, Manoela Domingues Martins, Lauro José Gregianin, Teresa Dalla Costa, Bibiana Verlindo de Araújo
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Pharmaceutics
Subjects:
methotrexate
osteosarcoma
pharmacokinetic model
Brazilian pediatric patients
Online Access:https://www.mdpi.com/1999-4923/16/9/1180
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https://www.mdpi.com/1999-4923/16/9/1180

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