Rodent islet amyloid polypeptide (IAPP) selectively enhances GABAA receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells

Islet amyloid polypeptide (IAPP, amylin) is a peptide hormone that plays an important role in glucose homeostasis but has been implicated in the pathophysiology of type 2 diabetes and Alzheimer’s disease. However, its effect on neurotransmission in the hippocampus remains poorly understood. Here, we...

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Bibliographic Details
Main Authors: Olga Netsyk, Sergiy V. Korol, Gunilla T. Westermark, Bryndis Birnir, Zhe Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cellular Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1531790/full
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