Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling

Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling

Abstract Transformation of cardiac fibroblasts into matrix-producing myofibroblasts plays an important role in tissue repair and fibrosis after myocardial injury. Tcf21 is a basic helix-loop-helix transcription factor that is essential for the development of cardiac fibroblasts and the epicardium. M...

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Main Authors: Yusuke Baba, Yoshiro Maezawa, Naomichi Kondo, Takuya Minamizuka, Haruhide Udagawa, Shintaro Ide, Kana Ide, Naoya Teramoto, Ayano Yamaguchi, Hiyori Kaneko, Shinichiro Funayama, Hisaya Kato, Mayumi Shoji, Kazuto Aono, Makoto Miyabayashi, Tetta Sato, Takumi Kitamoto, Yusuke Yagyu, Ryoichi Ishibashi, Masaya Koshizaka, Yusuke Endo, Masato Kanda, Minoru Takemoto, Naoya Takayama, Kazuki Yasuda, Yoshio Kobayashi, Koutaro Yokote
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Tcf21
Pdgfrb
Erk
Cardiac fibrosis
Cardiac fibroblasts
Matrix production
Online Access:https://doi.org/10.1038/s41598-025-13102-3
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https://doi.org/10.1038/s41598-025-13102-3

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