Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer

Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer

Background Many cancer patients do not obtain clinical benefit from immune checkpoint inhibition. Checkpoint blockade targets T cells, suggesting that tyrosine kinase activity profiling of baseline peripheral blood mononuclear cells may predict clinical outcome.Methods Here a total of 160 patients w...

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Main Authors: Joachim G J V Aerts, Ron H J Mathijssen, Sjoerd H van der Burg, Reinhard Dummer, Reno Debets, Mandy van Brakel, Ellen Kapiteijn, Daan P Hurkmans, Els M E Verdegaal, Sabrina A Hogan, Rik de Wijn, Lies Hovestad, Dianne M A van den Heuvel, Rob Ruijtenbeek, Marij J P Welters, Edwin A Basak, Herbert M Pinedo, Cor H J Lamers, Harmen J G van de Werken, John P Groten, Mitchell P Levesque
Format: Article
Language:English
Published: BMJ Publishing Group 2020-10-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/2/e001607.full
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https://jitc.bmj.com/content/8/2/e001607.full

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