Doublecortin regulates the mitochondrial-dependent apoptosis in glioma via Rho-A/Net-1/p38-MAPK signaling

Doublecortin regulates the mitochondrial-dependent apoptosis in glioma via Rho-A/Net-1/p38-MAPK signaling

Abstract Doublecortin (DCX) is a microtubule-associated protein known to be a key regulator of neuronal migration and differentiation during brain development. However, the role of DCX, particularly in regulating the survival and growth of glioma cells, remains unclear. In this study, we utilized CR...

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Main Authors: Iqra Nadeem, Zhou Han, Hong Xiaoliang, Seyram Yao Adzraku, Piniel Alphayo Kambey, Kouminin Kanwore, Mu Peipei, Adebayo Oluwafemi Adekunle, Joseph Adu-Amankwaah, Abiola Abdulrahman Ayanlaja, Yi Zheng, Gao Dianshuai, Xiaomei Liu, Yuanjian Song
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Doublecortin
CRISPR/Cas 9
Glioma
Apoptosis
Mitochondria
Online Access:https://doi.org/10.1186/s10020-024-01021-4
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https://doi.org/10.1186/s10020-024-01021-4

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