Ketamine and olanzapine alter behaviour and prefrontal-cortex BDNF differentially in male and female rats

Ketamine and olanzapine alter behaviour and prefrontal-cortex BDNF differentially in male and female rats

Abstract Schizophrenia is a severe chronic neuropsychiatric disorder with a wide-range of cognitive and mental deficits and different categories of symptoms including positive, negative, and cognitive symptoms. In rodents, sub-chronic ketamine administration is a common method to induce a schizophre...

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Bibliographic Details
Main Authors: Kalin Manooki, Mahdieh Gholami, Maryam Eslami, Salar Vaseghi, Batool Ghorbani Yekta
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Ketamine
Olanzapine
Schizophrenia
Sex differences
Brain-derived neurotrophic factor (BDNF)
Prefrontal cortex
Online Access:https://doi.org/10.1038/s41598-025-15499-3
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https://doi.org/10.1038/s41598-025-15499-3

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