Miniaturized Modular Click Chemistry‐enabled Rapid Discovery of Unique SARS‐CoV‐2 Mpro Inhibitors With Robust Potency and Drug‐like Profile

Miniaturized Modular Click Chemistry‐enabled Rapid Discovery of Unique SARS‐CoV‐2 Mpro Inhibitors With Robust Potency and Drug‐like Profile

Abstract The COVID‐19 pandemic has required an expeditious advancement of innovative antiviral drugs. In this study, focused compound libraries are synthesized in 96‐ well plates utilizing modular click chemistry to rapidly discover potent inhibitors targeting the main protease (Mpro) of SARS‐CoV‐2....

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Main Authors: Mianling Yang, Myoung Kyu Lee, Shenghua Gao, Letian Song, Hye‐Yeon Jang, Inseong Jo, Chun‐Chiao Yang, Katharina Sylvester, Chunkyu Ko, Shuo Wang, Bing Ye, Kai Tang, Junyi Li, Manyu Gu, Christa E. Müller, Norbert Sträter, Xinyong Liu, Meehyein Kim, Peng Zhan
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
click chemistry
direct screening
main protease
miniaturized synthesis
non‐covalent inhibitors
SARS‐CoV‐2
Online Access:https://doi.org/10.1002/advs.202404884
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https://doi.org/10.1002/advs.202404884

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