Structure of MICU from non-metazoan Dictyostelium discoideum reveals unique characteristics

Abstract In most eukaryotes, the mitochondrial calcium uniporter (MCU) mediates Ca2+ influx into the mitochondrial matrix through a process regulated by MICUs and the EMRE. In Dictyostelium discoideum, a model organism for amoebozoans that lack an EMRE, the MCU complex consists solely of the MCU and...

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Bibliographic Details
Main Authors: Minwoo Jin, Jihyeong Yang, Jongseo Park, Hyunwoo Kim, Soo Hyun Eom
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08218-1
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