Fluoxetine and agomelatine mitigate anhedonic and hepatic changes in chronic restraint stress rat model

Fluoxetine and agomelatine mitigate anhedonic and hepatic changes in chronic restraint stress rat model

Abstract Chronic stress, a common condition in modern life, is increasingly connected to a variety of medical concerns, including liver damage. Despite being one of the body’s most resilient organs, the liver is yet susceptible to the harmful effects of chronic stress. This study aimed to investigat...

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Main Authors: Wedad S. Sarawi, Norah K. Algarzae, Nada M. Alharbi, Ahlam M. Alhusaini, Layan M. Akkam, Reem E. Alsharidah, Latifah S. Alrasheed, Hala A. Attia, Iman H. Hasan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Fluoxetine
Agomelatine
Liver function
Chronic restraint stress
Oxidative stress
Caspase-3
Online Access:https://doi.org/10.1038/s41598-025-06339-5
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https://doi.org/10.1038/s41598-025-06339-5

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