Triple-effect correction for Cell Painting data with contrastive and domain-adversarial learning

Abstract Cell Painting (CP), as a high-throughput imaging technology, generates extensive cell-stained imaging data, providing unique morphological insights for biological research. However, CP data contains three types of technical effects, referred to as triple effects, including batch effects, gr...

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Bibliographic Details
Main Authors: Chengwei Yan, Yu Zhang, Jiuxin Feng, Heyang Hua, Zhihan Ruan, Zhen Li, Siyu Li, Chaoyang Yan, Pingjing Li, Jian Liu, Shengquan Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62193-z
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