Pregnancy level of estradiol attenuated virus-specific humoral immune response in H5N1-infected female mice despite inducing anti-inflammatory protection

Pregnancy level of estradiol attenuated virus-specific humoral immune response in H5N1-infected female mice despite inducing anti-inflammatory protection

Estradiol, a major female steroid produced during pregnancy, has been reported to protect ovariectomized animals against H1N1 influenza infections via its anti-inflammatory effects. However, it remains unclear why pregnant women with high gestational estradiol levels are highly susceptible to influe...

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Bibliographic Details
Main Authors: Courtney L. Finch, Anding Zhang, Martina Kosikova, Toshiaki Kawano, Marcela F. Pasetti, Zhiping Ye, Jill R. Ascher, Hang Xie
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Pregnancy level of estradiol
avian influenza
humoral immunity
Th2 response
sex-biased
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1648184
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https://www.tandfonline.com/doi/10.1080/22221751.2019.1648184

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