Lactate-related gene signatures as prognostic predictors and comprehensive analysis of immune profiles in nasopharyngeal carcinoma

Lactate-related gene signatures as prognostic predictors and comprehensive analysis of immune profiles in nasopharyngeal carcinoma

Abstract Objectives Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with high rates of morbidity and mortality, largely because of its late diagnosis and metastatic potential. Lactate metabolism and protein lactylation are thought to play roles in NPC pathogenesis by modulating the tumor...

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Main Authors: Changlin Liu, Chuping Ni, Chao Li, Hu Tian, Weiquan Jian, Yuping Zhong, Yanqing Zhou, Xiaoming Lyu, Yuanbin Zhang, Xiao-Jun Xiang, Chao Cheng, Xin Li
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Nasopharyngeal carcinoma
Lactylation-related genes
Infiltrating immunocytes
Machine learning algorithms
GEO
Online Access:https://doi.org/10.1186/s12967-024-05935-9
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https://doi.org/10.1186/s12967-024-05935-9

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