Clinical Characteristics Related to Central Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma: A Retrospective Study of 916 Patients
Background. Papillary thyroid carcinoma (PTC) is a form of thyroid cancer with high risk of cervical lymph node metastasis. Aim. The aim of this study was to investigate the incidence and the predictive factors for occult ipsilateral central lymph node (CLN) metastasis in the patients with papillary...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/385787 |
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| author | Lie-Hao Jiang Chao Chen Zhuo Tan Xiao-Xiao Lu Si-Si Hu Qing-Liang Wang Xiu-Xiu Hou Jun Cao Ming-Hua Ge |
| author_facet | Lie-Hao Jiang Chao Chen Zhuo Tan Xiao-Xiao Lu Si-Si Hu Qing-Liang Wang Xiu-Xiu Hou Jun Cao Ming-Hua Ge |
| author_sort | Lie-Hao Jiang |
| collection | DOAJ |
| description | Background. Papillary thyroid carcinoma (PTC) is a form of thyroid cancer with high risk of cervical lymph node metastasis. Aim. The aim of this study was to investigate the incidence and the predictive factors for occult ipsilateral central lymph node (CLN) metastasis in the patients with papillary thyroid carcinoma. Methods. A total of 916 PTC patients (1017 lesions) undergoing central lymph node dissection in our hospital from 2005 to 2011 were enrolled. The relationship between CLN metastasis and clinical factors such as gender, age, tumor size, tumor number, capsule invasion, and tumor location was analyzed. Results. Occult CLN metastasis was observed in 52.41% (533/1017) of PTC lesions, respectively. Multivariate analysis showed that age ≤ 35 years, tumor size > 1.5 cm, present capsule invasion/extracapsular invasion, and tumor located in upper/middle pole/whole lobe were risk factors of CLN metastasis. Conclusions. Tumor located in upper/middle pole/whole lobe, less than 35 years old, tumor size > 1.5 cm, and present capsule invasion/extracapsular invasion were risk factors of CLN metastasis. We recommend performing ipsilateral prophylactic CLN dissection in cN0 PTC patients. |
| format | Article |
| id | doaj-art-fd55e4dc81774c8186aac23c32d22cbd |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-fd55e4dc81774c8186aac23c32d22cbd2025-02-03T01:32:04ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/385787385787Clinical Characteristics Related to Central Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma: A Retrospective Study of 916 PatientsLie-Hao Jiang0Chao Chen1Zhuo Tan2Xiao-Xiao Lu3Si-Si Hu4Qing-Liang Wang5Xiu-Xiu Hou6Jun Cao7Ming-Hua Ge8Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaDepartment of Head and Neck Surgery, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaDepartment of Head and Neck Surgery, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaZhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaDepartment of Head and Neck Surgery, Zhejiang Province Cancer Hospital, 38 Guangji Road, Gongshu District, Hangzhou 310022, ChinaBackground. Papillary thyroid carcinoma (PTC) is a form of thyroid cancer with high risk of cervical lymph node metastasis. Aim. The aim of this study was to investigate the incidence and the predictive factors for occult ipsilateral central lymph node (CLN) metastasis in the patients with papillary thyroid carcinoma. Methods. A total of 916 PTC patients (1017 lesions) undergoing central lymph node dissection in our hospital from 2005 to 2011 were enrolled. The relationship between CLN metastasis and clinical factors such as gender, age, tumor size, tumor number, capsule invasion, and tumor location was analyzed. Results. Occult CLN metastasis was observed in 52.41% (533/1017) of PTC lesions, respectively. Multivariate analysis showed that age ≤ 35 years, tumor size > 1.5 cm, present capsule invasion/extracapsular invasion, and tumor located in upper/middle pole/whole lobe were risk factors of CLN metastasis. Conclusions. Tumor located in upper/middle pole/whole lobe, less than 35 years old, tumor size > 1.5 cm, and present capsule invasion/extracapsular invasion were risk factors of CLN metastasis. We recommend performing ipsilateral prophylactic CLN dissection in cN0 PTC patients.http://dx.doi.org/10.1155/2014/385787 |
| spellingShingle | Lie-Hao Jiang Chao Chen Zhuo Tan Xiao-Xiao Lu Si-Si Hu Qing-Liang Wang Xiu-Xiu Hou Jun Cao Ming-Hua Ge Clinical Characteristics Related to Central Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma: A Retrospective Study of 916 Patients International Journal of Endocrinology |
| title | Clinical Characteristics Related to Central Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma: A Retrospective Study of 916 Patients |
| title_full | Clinical Characteristics Related to Central Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma: A Retrospective Study of 916 Patients |
| title_fullStr | Clinical Characteristics Related to Central Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma: A Retrospective Study of 916 Patients |
| title_full_unstemmed | Clinical Characteristics Related to Central Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma: A Retrospective Study of 916 Patients |
| title_short | Clinical Characteristics Related to Central Lymph Node Metastasis in cN0 Papillary Thyroid Carcinoma: A Retrospective Study of 916 Patients |
| title_sort | clinical characteristics related to central lymph node metastasis in cn0 papillary thyroid carcinoma a retrospective study of 916 patients |
| url | http://dx.doi.org/10.1155/2014/385787 |
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