ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP–Wnt pathway

ELTD1 inhibits differentiation of hemogenic endothelium progenitors from human embryonic stem cells through the HPIP–Wnt pathway

Abstract Human embryonic stem cells (hESCs) serve as an ideal cell source for generating hematopoietic stem cells (HSCs). In embryonic hematopoiesis, hemogenic endothelium has been identified as a source of HSCs, yet the regulatory mechanisms remain elusive. Here, through dynamic gene expression pro...

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Main Authors: Qian Luo, Yijin Chen, Honghu Li, Yan Long, Wei Shan, Xiangjun Zeng, Shuyang Cai, Ye Meng, Cong Wei, Yulin Xu, Ruxiu Tie, Yi Luo, Pengxu Qian, Meng Zhang, He Huang
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01473-6
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https://doi.org/10.1038/s12276-025-01473-6

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