Large-scale EM data reveals myelinated axonal changes and altered connectivity in the corpus callosum of an autism mouse model

Large-scale EM data reveals myelinated axonal changes and altered connectivity in the corpus callosum of an autism mouse model

IntroductionAutism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental disorders with complex etiologies, including genetic, environmental, and neuroanatomical factors. While the exact mechanisms underlying ASD remain unclear, structural abnormalities in the brain offer valuabl...

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Main Authors: Guoqiang Zhao, Ao Cheng, Jiahao Shi, Peiyao Shi, Jun Guo, Chunying Yin, Hafsh Khan, Jiachi Chen, Pengcheng Wang, Jiao Chen, Ruobing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Neuroinformatics
Subjects:
Shank3b
autism spectrum disorder
corpus callosum
serial scanning electron microscopy
myelinated axons
Online Access:https://www.frontiersin.org/articles/10.3389/fninf.2025.1563799/full
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https://www.frontiersin.org/articles/10.3389/fninf.2025.1563799/full

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