Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer

Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer

Abstract Background Non-coding RNAs (ncRNAs) in human cells constitute a substantial portion of the transcriptome but do not lead to protein synthesis. Among them, long non-coding RNAs (lncRNAs, > 200 nucleotides long) are fascinating in their ability to orchestrate critical cellular functions th...

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Bibliographic Details
Main Authors: Shubham Sharma, Jérémie Mitteaux, Angélique Pipier, Marc Pirrotta, Marie-José Penouilh, David Monchaud, Bhaskar Datta
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
Colorectal cancer
Long non-coding RNA
G-quadruplex
Ligands
Molecular helicases
Online Access:https://doi.org/10.1186/s12915-025-02322-8
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https://doi.org/10.1186/s12915-025-02322-8

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