Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway

Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway

BackgroundRenal interstitial fibrosis (RIF) represents the final common pathway in nearly all progressive chronic kidney diseases. This study aimed to investigate the effects of Yishen-Huoxue formula (YHF) on RIF and its underlying mechanisms.MethodsUnilateral ureteral obstruction (UUO) model was ap...

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Bibliographic Details
Main Authors: Mouying Du, Chun Yao, Qinke Lv, Aimei Gong, Yonghua Zhu, Jiayuan Li, Jian Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Medicine
Subjects:
renal interstitial fibrosis
Yishen-Huoxue formula
miR-210
HIF-1α
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1530092/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1530092/full

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