Controlling CRISPR-Cas9 genome editing in human cells using a molecular glue degrader

Controlling CRISPR-Cas9 genome editing in human cells using a molecular glue degrader

CRISPR-Cas9-based genome editors can precisely target and edit genes efficiently. However, prolonged Cas9 activity poses challenges for laboratory experiments and raises safety concerns for therapeutic applications due to unintended consequences such as off-target editing, genotoxicity, immunogenici...

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Bibliographic Details
Main Authors: Namita Khajanchi, Vrusha Patel, Ronak Dua, Meha Kabra, Bikash R. Pattnaik, Krishanu Saha
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
gene therapy
CRISPR
cell therapy
Cas9
degron
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001945
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