Controlling CRISPR-Cas9 genome editing in human cells using a molecular glue degrader
CRISPR-Cas9-based genome editors can precisely target and edit genes efficiently. However, prolonged Cas9 activity poses challenges for laboratory experiments and raises safety concerns for therapeutic applications due to unintended consequences such as off-target editing, genotoxicity, immunogenici...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253125001945 |
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