Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies

Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies

Abstract Background Primary cilia mediate vertebrate development and growth factor signalling. Defects in primary cilia cause inherited developmental conditions termed ciliopathies. Ciliopathies often present with cystic kidney disease, a major cause of early renal failure. Currently, only one drug,...

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Main Authors: Claire E. L. Smith, Andrew J. Streets, Alice V. R. Lake, Subaashini Natarajan, Sunayna K. Best, Katarzyna Szymanska, Magdalena Karwatka, Thomas Stevenson, Rachel Trowbridge, Gary Grant, Sushma N. Grellscheid, Richard Foster, Ciaran G. Morrison, Georgia Mavria, Jacquelyn Bond, Albert C. M. Ong, Colin A. Johnson
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00847-1
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https://doi.org/10.1038/s43856-025-00847-1

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