MHC-I upregulation by macbecin II in the solid tumors potentiates the effect of active immunotherapy

MHC-I upregulation by macbecin II in the solid tumors potentiates the effect of active immunotherapy

Abstract We aimed to restore MHC-I expression on the surface of solid tumors including breast cancer and melanoma cells to regain sensitivity to immunotherapy and suppress metastatic progression. We screened a natural compound library and identified macbecin II as a reagent that upregulates MHC-I ex...

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Bibliographic Details
Main Authors: Ravindra Pramod Deshpande, Kerui Wu, Shih-Ying Wu, Abhishek Tyagi, Eleanor C Smith, Jee-Won Kim, Kounosuke Watabe
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:EMBO Molecular Medicine
Subjects:
Active Immunotherapy
Anti-PD-1
Breast Cancer
Macbecin II
MHC-I
Online Access:https://doi.org/10.1038/s44321-025-00213-7
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https://doi.org/10.1038/s44321-025-00213-7

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