Mogat1 drives metabolic adaptations to evade immune surveillance

Abstract Immune checkpoint blockade (ICB) therapies for solid tumors often fail due to resistance, necessitating new strategies. While efforts target IFNγ signaling or antigen presentation, other immune evasion mechanisms are unclear. Here, we identify Monoacylglycerol O-Acyltransferase 1 (Mogat1) a...

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Bibliographic Details
Main Authors: Huan Wei, Congyi Niu, Yue Shi, Yingfei Fang, Chengheng Yang, Jian Liu, Zhenjie Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62134-w
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