Bioinformatic analysis and experimental verification reveal expansion of monocyte subsets with an interferon signature in systemic lupus erythematosus patients

Bioinformatic analysis and experimental verification reveal expansion of monocyte subsets with an interferon signature in systemic lupus erythematosus patients

Abstract Background Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by chronic inflammation and multi-organ damage. A central factor in SLE pathogenesis is the excessive production of type I interferon (IFN-I), which drives immune dysregulation. Monocytes, key compo...

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Bibliographic Details
Main Authors: Jimin Zhang, Wuwei Zhuang, Yan Li, Chaoqiong Deng, Jingxiu Xuan, Yuechi Sun, Yan He
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Arthritis Research & Therapy
Subjects:
Systemic lupus erythematosus
Single-cell RNA sequencing
Type I interferon
Interferon-stimulated genes
CD14+SIGLEC1+IRF7+ monocytes
Online Access:https://doi.org/10.1186/s13075-025-03560-5
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https://doi.org/10.1186/s13075-025-03560-5

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